If you don't want to use OneDrive and don't want users to see OneDrive then here are three things you can do:
1. Use this group policy to disable OneDrive appearing in File Explorer:
Computer Configuration\Administrative Templates\Windows Components\OneDrive\Prevent the usage of OneDrive for file storage
2. Use group policy preferences to prevent OneDrive at startup:
Create a Delete registry preference OneDrive value in this registry key HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Run
So it looks like this:
3. Use Applocker to prevent users from launching OneDrive.